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Orkal (Amlodipine)

The Cluster Randomized Usual Care versus Caduet Investigation Assessing Long-term-risk (CRUCIAL) trial demonstrated that a proactive multifactorial intervention (PMI) approach (based on single-pill Orkal/atorvastatin) resulted in a greater reduction in calculated Framingham 10-year coronary heart disease (CHD) risk compared with usual care (UC) among hypertensive patients with additional risk factors.

Other names for this medication:
Amlodipine, Norvasc, Abis, Abloom, Actapin, Amlodin, Amlotens, Amlovas, Amlovasc, Amlozek, Amparo, Amtas, Amvasc, Amze, Anexa, Arteriosan, Arterium, Asomex, Astudal, Avistar, Calchek, Cardisan, Cardivas, Cordil, Coroval, Dafiro, Dafor, Divask, Dopin, Duactin, Esam, Exforge, Gensia, Hipres, Imped, Ipin, Istin, Kaprin, Lama, Locard, Lodipine, Lofral, Lopin, Monovas, Myodura, Nicord, Nipidol, Noloten, Orkal, Perivasc, Perten, Roxflan, Rustin, Stamlo, Tenox, Tensivask, Tervalon, Vamlo, Vasocard, Vazkor, Vazotal, Vilpin, Zorem,

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Orkal is used alone or together with other medicines to lower hypertension (high blood pressure) in adults and children. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.

Orkal is also used to relieve chronic stable angina (chest pain) in adults.

Orkal is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers blood pressure. A lower blood pressure will increase the supply of blood and oxygen to the heart.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Suspension
  • Tablet

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We describe a patient who presented with unilateral objective pulsatile tinnitus (PT) from an unusual spontaneous fistula between the internal carotid artery (ICA) and the internal jugular vein (IJV). The role of surgery in the management of gastrointestinal stromal tumors (GISTs) in the era of imatinib mesylate effectiveness.

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An empirical PEEP trial investigating plateau pressure response in these patients appears to be a reasonable strategy with minimal side effects. Additional changes in metalloproteinase profiles are observed after approximately 20 passage of several RPE lines in culture.

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They share the same properties as embryonic stem (ES) cells and can differentiate into several tissue cells, i.e., neurons, hematopoietic cells, and liver cells. At therapeutic concentrations, ddATP inhibits HIV replication by inhibiting HIV reverse transcriptase.

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Lymphocyte transformation induced by culture media supplemented with primate serum. The bactericidal agent is ineffective against all the Gram-negative bacilli so far tested. Clinical importance of innervation of the central ganglial region of the arterial system Our findings confirm the patterns of endometrial integrins and suggest important roles for integrins in the process of implantation and decidualization. Prescriptions for testosterone have increased dramatically over the past decade, since a testosterone-gel formulation was approved and since numerous studies reported an association between low serum testosterone and increased mortality.

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A Preclinical Model of Chronic Alcohol Consumption Reveals Increased Metastatic Seeding of Colon Cancer Cells in the Liver. On the basis of the most recent peer-reviewed publications, the first part of this article critically evaluates data regarding the epidemiology of ED in the aging population. TIME has ethical approval in the UK, and results will be published in a peer-reviewed journal.

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Measurements of the neuropeptides, using specific radioimmunoassays, in brain sections cut in three planes or in grossly dissected brain areas, showed that cLHRH-II occurs in low amounts throughout the brain whereas cLHRH-I is most abundant in the diencephalon. Although adolescents and young women who perceive noncontraceptive benefits after 6 months of use are more likely to continue, the expectation of such benefits does not correlate with continuation.

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A quantitative high-throughput chemotaxis assay using bioluminescent reporter cells. A carbon nanopore model to quantify structure and kinetics of ion electrosorption with in situ small-angle X-ray scattering. Sixty protein spots showed statistically significant intensity changes in at least one comparison.

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Thyroxine induces transition of red towards white muscle in cultured heart cells. Pediatric pulmonary arterial hypertension: on the eve of growing up.

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The high yields, and the similarities in morphology as well as putative hormonal influence suggest that this experimental system may serve as a good animal model for granulosa cell tumor and/or luteoma development in women. Adaptive dosing results in reduced pharmacokinetic variability and more consistent toxicity. The cellular receptor for urokinase-type plasminogen activator (uPAR) is a glycolipid-anchored membrane protein thought to play a primary role in the generation of pericellular proteolytic activity, and to be involved in cancer cell invasion and metastasis. Breast inflammatory gigantomastia in a context of immune-mediated diseases. The whole pleural cavity provided decrease of mechanical work of breathing.

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Purification and some properties of isocitrate lyase from Pinus pinea. In fact, agreement on standard definitions allows comparison of data in different contexts. This rapidly moving field now concentrates in particular, on the modulating effects these agents can have on cellular signalling pathways involved in the apoptotic, proliferative and angiogenic processes, perturbances to which, are common in many cancers. The first in vivo spatially-resolved field-gradient measurements of water self-diffusivity, D, in the stratum corneum (2.0 x 10(-6) cm(2)/s) and viable epidermis (8.5 x 10(-6) cm(2)/s) are reported. Finally, the MAPK Sty1, but not the eIF2alpha kinases, is essential for survival upon oxidative stress or heat shock, but not upon MMS treatment.

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The lipophilic carbocyanine fluorescent label DiI was injected in one eye of aldehyde-fixed embryonic or postnatal hamsters and the brains were examined using flat-mounts of the chiasm region, of the lateral surface of the brainstem, or of the midbrain tectum. Role of the dermis in differentiation of the nasolacrimal duct in Discoglossus pictus (anourous amphibian) In terms of system usability and functions, different levels of sophistication of and interaction performance with ENR systems exist in practice.

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However, spCSF-1 mediates macrophage activation and macrophage-related neural damage, whereas csCSF-1 inhibits macrophage activation and attenuates neuropathy. Reasons patients present to the emergency department might change during epidemics and be a valuable component of a disease surveillance system. By contrast, IETD only marginally protected the type II CEM cells. In addition, genetic defects that target the retina can lead to blindness.

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Compound 16 was found to be a highly potent vitamin D analogue with bioactivity similar to that of 25-hydroxyvitamin D3 in vivo. In the process, we compute various distributions: the numbers of irreducible substructures and their locations and sizes, parameterized in terms of the maximal number of mutually crossing arcs, k-1, and the minimal size of stacks sigma. Two thousand eight hundred eighty sero-negative first-time and repeat donations from Fayoum University Hospital blood bank were individually analysed by NAT for HIV, HBV and HCV.

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A case of follicular thyroid cancer appearing as an autonomous nodule on Tc-99m and I-123 thyroid scintigraphy is presented in addition to a pertinent review of the literature. Ovaries from dogs were obtained and corpora lutea (CL) macroscopically removed.

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Enantioselective formation of C-H, C-C, C-O and C-N bonds has been extensively studied using homogeneous asymmetric catalysts for many years. Using sediment cores to establish targets for the remediation of aquatic environments. Endocrine opthalmopathy-- new physiopathological viewpoints through the determination of T3, T4 and TSH following TRH stimulation Efforts to reduce the late toxicity associated with chemoradiation (CRT) for locally advanced head and neck squamous cell cancer (LA-HNSCC) have focused on radiotherapy (RT) dose de-escalation. The mode of disintegrant incorporation and modification of wheat starch had different effects on tablet properties of metronidazole formulations.

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This could jeopardize the validity of the robust Wald test by causing inflated type I error and lower coverage probability of the corresponding confidence interval than the nominal level. Copper acetate precipitated a fraction from serum ultrafiltrate which, when freed from copper, was stimulating to the initial growth of adult aorta tissue. The deutocerebrum must have been secondarily displaced towards the protocerebrum in pycnogonid ancestors. The convenient sample consisted of 12 subjects who had attended a pain rehabilitation program 6 years earlier. Calcium and magnesium can compete in either ACP species for manganese binding.

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In addition to significantly elevated blood glucose levels, diabetic rats had decreased mean body weight, lower levels of plasma estradiol, and higher plasma testosterone concentration, compared to age-matched controls. Examples of pKBHX prediction for molecular structures with multiple, nonequivalent hydrogen bond acceptors are presented.

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The relationship between GDF9 gene and reproductive performance was also discussed vass vs pagan min thangka in mammals. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM. Although RNA interference (RNAi) has emerged as an important tool for studying the effects of gene knockdown, it is still difficult to predict the success of RNAi effectors in human systems. Top ten emanations contributing to characteristics in different seasons were attempted to be described using comparisons based on common model strategy.

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Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. To circumvent the possibility that insufficient cross-homology existed to detect a papillomavirus genome with the mixed probe used, DNAs extracted from six papillomas were labeled and each used to probe reference blots that contained 25 cloned papillomavirus genomes excised from their vectors. Modelling the progression towards duodenal cancer among patients with familial polyposis on the basis of two different score profiles. IR-780 for prostate cancer diclofenac duo pharmaswiss 75 mg imaging was carried out in athymic nude mouse models and, acute toxicity of IR-780 was evaluated.

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The scrotum and testicles from 20 bulls aged 6 mo to 10 yr were obtained from a slaughterhouse and ultrasonically scanned to determine the normal echographic anatomy Ultrasonically, the normal bull testicle was homogeneous and moderately echogenic. somnus on day 6 of experimental BRSV infection bactrimel dosage calculations would result in disease enhancement and potentially an altered immune response when compared with single infection. Newly imported Tom40 was readily assembled into the TOM complex in mitochondria lacking any of the small Tom proteins.

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Altered progesterone receptor isoform expression remodels progestin responsiveness of baclofeno intrathecal vs epidural breast cancer cells. The Saccharomyces cerevisiae assay yielded geno- and cytotoxic responses in all complex untreated and centrifuged samples with high reproducibility.

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In this study the effects of total saponins brand 4 azen den bosch map of Panax notoginseng (TSPN) and electroacupuncture (EA) were compared. Results of blood culture and bronchoalveolar lavage led to the diagnosis of the first reported case of concomitant disseminated histoplasmosis and pulmonary coccidioidomycosis in an HIV-infected patient. Intra-atrial reentrant tachycardia with ambiguous data from activation mapping: what to do next? Utility of PCR in diagnosing complicated cases of unusual clinical manifestations of Salmonella enterica var.