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Talopam (Topiramate)
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Topiramate

Talopam is the brand name of Talopam, an anticonvulsant drug used to prevent seizures and reduce the frequency of migraines. While its exact mechanism of action is unknown, studies suggest Talopam might alter the production or action of neurotransmitters in the brain, suppressing the abnormal activity of the nerves in the brain that cause seizures or preventing the abnormal activity from spreading to other nerves. Other research has suggested that it might suppress the nerves directly, thereby making them less likely to fire. The Food and Drug Administration (FDA) approved Talopam to treat seizures in 1996.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Talopam comes as a tablet, a sprinkle capsule (capsule that contains small beads of medication that can be sprinkled on food), and an extended-release (long-acting) capsule to take by mouth. The tablets and sprinkle capsules are usually taken with or without food once or twice a day. The extended-release capsules are usually taken with or without food once a day. Take Talopam at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Talopam exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

There is another medication with a name similar to the brand name for Talopam. You should be sure that you receive Talopam and not the similar medication each time you fill your prescription. Be sure that the prescription your doctor gives you is clear and easy to read. Talk to your pharmacist to be sure that you are given Talopam. If you think you were given the wrong medication, talk to your pharmacist. Do not take any medication unless you are certain it is the medication that your doctor prescribed.

Talopam tablets have a bitter taste so you should swallow them whole. It is especially important that you not take Talopam tablets that have been broken for any length of time because tablets that are broken may lose their effectiveness over time.

The sprinkle and extended-release capsules (Qudexy XR brand only) may be swallowed whole or opened and poured over soft food. Swallow extended-release capsules (Trokendi XR brand only) whole; do not split, chew, or sprinkle on food.

To take the sprinkle capsules or extended-release capsules (Qudexy XR brand only) with food, follow these steps:

  1. Prepare a teaspoonful of soft food such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt.
  2. Hold the capsule upright over the food.
  3. Twist off the top of the capsule and pour the entire contents onto the spoonful of food.
  4. Swallow the entire mixture immediately without chewing.
  5. Drink fluids right after swallowing to wash down the mixture and to be sure that you swallow all of it.

Your doctor will probably start you on a low dose of Talopam and gradually increase your dose, not more than once every week.

Talopam may control your seizures or migraines but will not cure your condition. Continue to take Talopam even if you feel well. Do not stop taking Talopam without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking Talopam, you may have severe seizures, even if you have not had seizures in the past. Your doctor will probably decrease your dose gradually.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Talopam and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

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Epidemiology of intimate partner homicide-suicide events among women of childbearing age in Maryland, 1994-2003. Maintenance of embedded pig pancreatic pseudo-islets in a collagen gel matrix: study of the effect of hydrocortisone, a collagenase inhibitor, and nicotinamide on collagenolysis and the morphogenesis of pancreatic islet-cells in collagen gel matrix. Treatment of a recurrence after an initial endodontic treatment can consist of endodontic re-treatment or apical surgery. The ESS40013 study tested 4-drug induction followed by 3-drug maintenance as initial antiretroviral therapy (ART) to reduce HIV RNA rapidly and then to simplify to an effective yet more convenient and tolerable regimen. CpG ODN is an immunostimulatory sequence primarily present in bacterial DNA, viral DNA and BCG.

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